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Updated: May 14, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Methyl 2,4-dihy-droxy-5-(4-nitro-benzamido)-benzoate
Syeda Sohaila Naz1, Nazar Ul Islam, M Nawaz Tahir
1University of Peshawar, Institute of Chemical Sciences, Peshawar, Pakistan.
Abstract:
In the title compound, C(15)H(12)N(2)O(7), the dihedral angle between the aromatic rings is 4.58 (13)° and the nitro group is rotated from its attached ring by 18.07 (17)°. Intra-molecular N-H⋯O and O-H⋯O hydrogen bonds generate S(5) and S(6) rings, respectively. In the crystal, mol-ecules are linked by O-H⋯O hydrogen bonds, generating [001] C(7) chains. The chains are linked by C-H⋯O inter-actions, forming a three-dimensional network, which incorporates R(2) (2)(7) and R(2) (2)(10) loops.
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