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Updated: May 14, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Methyl 2,4-dihy-droxy-5-(2-methyl-propanamido)-benzoate
Syeda Sohaila Naz1, Nazar Ul Islam, M Nawaz Tahir
1University of Peshawar, Institute of Chemical Sciences, Peshawar, Pakistan.
Abstract:
In the title compound, C(12)H(15)NO(5), the dihedral angle between the benzene ring and the C atoms of the terminal isopropyl group is 83.48 (16)°. Intra-molecular N-H⋯O and O-H⋯O hydrogen bonds generate S(5) and S(6) rings, respectively. In the crystal, mol-ecules are linked by O-H⋯O hydrogen bonds, generating C(7) chains propagating in [001]. Weak aromatic π-π stacking [centroid-centroid separation = 3.604 (3) Å] is also observed.
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