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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Methyl 4'-(4-fluoro-phen-yl)-1'-methyl-3'-nitro-methyl-2-oxospiro-[indoline-3,2'-pyrrolidine]-3'-carboxyl-ate
B K Revathi1, S Sathya, G Usha
1Post Graduate and Research Department of Physics, Queen Mary's College, Chennai-4, Tamilnadu, India.
Abstract:
In the title compound, C(21)H(20)FN(3)O(5), the the pyrrolidine ring makes dihedral angles of 84.91 (6) and 62.38 (7)° with the oxindole unit and the fluoro-phenyl ring, respectively. The pyrrolidine ring assumes an envelope conformation with the spiro C atom as the flap. The crystal packing features weak N-H⋯N and C-H⋯O hydrogen bonds.
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