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Hypoxia01:23

Hypoxia

Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
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Autoxidation of Ethers to Peroxides and Hydroperoxides

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Structure and Nomenclature of Ethers02:28

Structure and Nomenclature of Ethers

Structure and Bonding
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Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
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Desoxyhemigossypol 6-methyl ether.

Vyacheslav V Uzbekov1, Samat A Talipov, Bakhtiyar T Ibragimov

  • 1Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan, M. Ulugbek str. 83, Tashkent, 100125 Uzbekistan.

Acta Crystallographica. Section E, Structure Reports Online
|February 21, 2013
PubMed
Summary

A novel sesquiterpene was identified in pathogen-infected cotton (Gossypium barbadense) stele tissue. Structural analysis revealed specific molecular arrangements and intermolecular interactions in its crystalline form.

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Area of Science:

  • Plant biochemistry
  • Organic chemistry
  • Crystallography

Background:

  • Pathogen infection in Gossypium barbadense can induce the production of secondary metabolites.
  • Sesquiterpenes are a class of organic compounds with diverse biological activities.

Purpose of the Study:

  • To isolate and characterize a sesquiterpene from pathogen-infected Gossypium barbadense.
  • To elucidate the crystal structure and intermolecular interactions of the isolated sesquiterpene.

Main Methods:

  • Isolation of the sesquiterpene from plant tissue.
  • Single-crystal X-ray diffraction analysis to determine molecular and crystal structure.

Main Results:

  • A sesquiterpene, C(16)H(18)O(3), was successfully isolated.
  • The crystal structure revealed two molecules in the asymmetric unit with a dihedral angle of 86.48° between naphtho-furan systems.
  • Molecules form centrosymmetric tetramers via O-H⋯O hydrogen bonds and are arranged in layers by pi-stacking and C-H⋯O contacts.

Conclusions:

  • The study reports the isolation and structural characterization of a novel sesquiterpene from Gossypium barbadense.
  • The crystal packing analysis provides insights into the intermolecular forces governing the solid-state structure.