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Updated: May 14, 2026
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An Epithelial Abrasion Model for Studying Corneal Wound Healing
Published on: December 29, 2021
[Methods for sealing of corneal perforations]
O Samoilă1, Lăcrămioara Totu, M Călugăru
1Clinica Oftalmologica, Cluj-Napoca.
Oftalmologia (Bucharest, Romania : 1990)
|February 22, 2013
Summary
Scleral patch and amniotic membrane offer effective solutions for sealing perforated corneas when corneal transplants are unavailable. These methods demonstrate good corneal restoration in clinical cases.
Area of Science:
- Ophthalmology
- Regenerative Medicine
Background:
- Corneal ulcers and perforations necessitate surgical repair for volume restoration and reepithelialization.
- Corneal transplantation is the standard for repairing large defects but faces availability challenges, particularly in developing nations.
Observation:
- Two cases of perforated cornea were treated with alternative sealing methods.
- Case 1: A large peripheral corneal defect was sealed using a scleral patch.
- Case 2: A small central corneal perforation was sealed with a multilayered amniotic membrane.
Findings:
- Both scleral patch and amniotic membrane effectively sealed the corneal defects.
- Over 12 months of follow-up, both cases showed significant corneal restoration.
- Clinical examination and corneal topography confirmed successful outcomes in both patients.
Implications:
- Scleral grafts and amniotic membranes serve as viable alternatives to corneal transplants for sealing corneal defects.
- These biomaterials offer accessible and effective solutions for managing corneal perforations, especially where transplantation is limited.
