Related Experiment Video

Updated: May 14, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
09:04

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

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[Severe malarial infection in adults aged over 18 years: one-year experience]

Luis Arencibia Pita1, Martha Rosendo Jiménez, Aracelis Serrano Murillo

  • 1Clínica Meditex Luanda, Angola. arencibiapita@yahoo.es

Revista Cubana De Medicina Tropical
|February 22, 2013
PubMed

Insights

Severe malaria, a major cause of ICU admissions in Africa, primarily affects the brain and liver, irrespective of parasite levels. This study in Luanda found lower mortality rates than previously reported.

Area of Science:

  • Tropical medicine
  • Infectious diseases
  • Clinical research

Context:

  • Severe malaria is a leading cause of intensive care unit (ICU) admission in many African nations.
  • Understanding organ-specific impacts and parasitemia levels is crucial for managing severe malaria.
  • This study was conducted in Luanda, Angola, from January to December 2004.

Purpose:

  • To identify the most frequently affected organs in severe malaria cases.
  • To investigate the influence of parasitemia levels on organ involvement.
  • To evaluate common complications and mortality rates associated with severe malaria.

Summary:

  • A cross-sectional descriptive study included critically ill patients over 18 with Apache II scores >20.
  • The clinical cerebral form was most prevalent (42.2%), often with low parasitemia (<1000/mm³).
  • Brain and hepatic complications were most serious and frequent, showing no correlation with admission parasitemia levels.

Impact:

  • The findings highlight brain and liver as key target organs in severe malaria.
  • Reduced fluid volume was a common complication, successfully managed with fluid intake.
  • The study reported a lower mortality rate compared to previous research, suggesting potential improvements in care or specific patient demographics.

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