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Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
Published on: January 7, 2018
[Screen value of anthropometric indices for hyperglycemia]
Xiaoqian Liu1, Suyun Li, Yumei Zhang
1School of Public Health, Peking University, Beijing 100191, China. castawayliu@126.com
Objective:
The study was to examine whether waist-to-thigh ratio (WTR) performed better than waist-to-height ratio (WHtR), waist-to-hip ratio (WHR), waist circumference (WC), or body mass index (BMI) in relation to hyperglycemia (fasting plasma glucose > or = 5.6 mmol/L) among government employee.
Methods:
A cluster sampling was conducted in Beijing ShiJitan Hospital in August 2010. 1280 government employee were examined on height, weight, WC, hip circumference, thigh circumference, fasting glucose and so on.
Results:
(1) The rate of hyperglycemia was 40.16%, increasing along with age. The level of WC, BMI, WHtR, WHR, WTR, SBP, DBP, AST, TC, TG, CRE, UA in hyperglycemia group was significantly higher than that of normal glucose group (P < 0. 001), but the level of HDL-C is lower than normal glucose group. Meanwhile, the prevalence rate of fat liver in hyperglycemia group was significantly higher than that of normal glucose group. (2) Receiver operating characteristic (ROC) curve analysis was used to measure the predictive hyperglycemia performance of each anthropometric measurement based on the area under the curve (AUC). AUC of WTR (0.716) was larger than that of WHtR (0.690) (P < 0.001), WHR (0.682) (P < 0.001), WC (0.682) (P < 0.001), and BMI (0.665) (P < 0.001) for hyperglycemia. In men, AUC of WTR (0.648) was larger than that of WHtR (0.611) (P < 0.001), WHR (0.614) (P < 0.001), WC (0.598) (P < 0.001), and BMI (0.587) (P < 0.001) for hyperglycemia. In women, the AUC of WTR (0.758) was smaller than that of WHtR (0.774) (P < 0.001), and WC (0.761) (P < 0.001), but larger than that of BMI (0.738) (P < 0.001) and WHR (0.732) (P < 0.001) for hyperglycemia. Stratified by age, in women who age > or = 35 years, the AUC of WTR (0.725) was larger than that of WHtR (0.716) (P < 0.001), WC (0.705) (P < 0.001), WHR (0.676) (P < 0.001) and BMI (0.665) (P < 0.001). (3) After adjustment for age and gender, logistic regression analyses showed that WTR have the strongest association with hyperglycemia (OR = 1.70, 95% CI 1.37 - 2.11; per 1 SD increment).
Conclusion:
Hyperglycemia is a serious health problem in government employee. WTR performed better than other four indices in all men and in women age > or = 35 for the association with hyperglycemia.
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