Related Experiment Video
Updated: May 14, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Dexamethasone iontophoresis for the treatment of nail psoriasis
1Monash Medical Centre, Southern Health, Melbourne, Victoria, Australia.
Background:
Severe nail psoriasis can impact significantly on quality of life and is difficult to treat.
Methods:
This is a retrospective study of all patients treated with dexamethasone iontophoresis weekly for at least 3 months at our specialist nail clinic between 1996 and 2011. Response to treatment was assessed on clinical photographs using the nail psoriasis severity index (NAPSI) scoring.
Results:
In all, 27 patients were assessed, of whom 81 per cent showed an improvement in their nails. The treatment was well tolerated, with only one patient reporting fissuring of the fingertips.
Conclusions:
Dexamethasone iontophoresis may be a useful treatment of this generally recalcitrant condition.
Related Concept Videos
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Transdermal Drug Delivery Systems
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Nephrotic Syndrome II : Assessment and Medical Management
