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Related Experiment Videos

Experimental pathogenicity of Aphanoascus spp.

J Cano1, E Mayayo, J Guarro

  • 1Unitat de Biologia i Microbiologia, Facultat de Medicina, Universitat de Barcelona, Reus, Tarragona, Spain.

Mycoses
|January 1, 1990
PubMed
Summary

Four Aphanoascus species caused peritoneal lesions in immunosuppressed mice, with fungal elements localized within nodules. Recovery rates varied, indicating organ-specific fungal persistence and limited systemic spread.

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Area of Science:

  • Medical Mycology
  • Immunology
  • Veterinary Pathology

Background:

  • The genus Aphanoascus comprises fungi with potential pathogenic capabilities.
  • Understanding the host-pathogen interactions of Aphanoascus species is crucial for diagnosing and treating infections.

Purpose of the Study:

  • To investigate the pathogenicity of four Aphanoascus species in an immunodepressed murine model.
  • To characterize the macroscopic and microscopic lesions induced by these fungi.
  • To assess the recovery rates and distribution of fungal elements within host tissues.

Main Methods:

  • Immunodepressed mice were inoculated intraperitoneally with conidia and mycelial macerates of four Aphanoascus species.
  • Macroscopic examination of peritoneal cavity and internal organs was performed.

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  • Fungal recovery was assessed on phytone-yeast extract agar after one month.
  • Histopathological examination of affected tissues was conducted.

    • Main Results:

    • All four Aphanoascus species induced nodular lesions in the peritoneal cavity, predominantly affecting the liver, spleen, diaphragm, and peritoneum.
    • Fungal recovery rates ranged from approximately 20% to 80%, varying by organ.
    • Histological analysis revealed the presence of ascospores and hyphal fragments within the central areas of the nodules.
    • Fungal elements were not detected in unaffected organs or intravascularly.

    Conclusions:

    • Aphanoascus species can cause significant lesions in the peritoneal cavity of immunodepressed mice.
    • The fungi appear to be localized within the induced nodules, with limited evidence of widespread dissemination.
    • These findings contribute to understanding the pathogenesis of Aphanoascus infections in a mammalian model.