Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antibody-directed drug discovery.

M E Wolff1, A McPherson

  • 1ImmunoPharmaceutics, Inc., San Diego, California 92127.

Nature
|May 24, 1990
PubMed
Summary
This summary is machine-generated.

Antibody-directed drug discovery leverages the immune system to identify target sites for drug ligands. This approach accelerates the creation of novel therapeutic entities.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

Physical review letters·2024
Same author

Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment.

Physical review letters·2022
Same author

The role of tissue type, sampling and nucleic acid purification methodology on the inferred composition of Pacific oyster (Crassostrea gigas) microbiome.

Journal of applied microbiology·2019
Same author

A retrospective study of past graduates of a residential life skills program for youth with physical disabilities.

Child: care, health and development·2014
Same author

A four-part ecological model of community-focused therapeutic recreation and life skills services for children and youth with disabilities.

Child: care, health and development·2012
Same author

A citation analysis of the influence on research of Skinner's verbal behavior.

The Behavior analyst·2012
Same journal

Daily briefing: How cooperation built the world.

Nature·2026
Same journal

Deep-sea oddities and boatloads of other new species - June's best science images.

Nature·2026
Same journal

From cloning to gene-editing: the enduring legacy of Dolly the sheep.

Nature·2026
Same journal

Time to give hydration breaks the red card? What science says about keeping cool.

Nature·2026
Same journal

Universities are relying on AI-detection software to catch cheating. How well do the programs work?

Nature·2026
Same journal

Daily briefing: 'Cyborg' cockroaches breathe underwater with printed suit.

Nature·2026
See all related articles

Area of Science:

  • Immunology
  • Medicinal Chemistry
  • Drug Discovery

Background:

  • The immune system possesses a unique ability to recognize and bind to specific molecular targets.
  • Traditional drug discovery methods can be time-consuming and may not fully exploit the chemical information available at target sites.

Purpose of the Study:

  • To introduce and explain the concept of antibody-directed drug discovery.
  • To highlight how this method utilizes immunological principles to enhance drug design.

Main Methods:

  • Harnessing the immune system's natural targeting capabilities.
  • Utilizing three-dimensional chemical information from target sites.
  • Employing antibody-based strategies for ligand identification.

Related Experiment Videos

Main Results:

  • Accelerated identification of potential drug ligands.
  • Improved access to complex chemical information at target sites.
  • Streamlined design of new therapeutic entities.

Conclusions:

  • Antibody-directed drug discovery offers a powerful paradigm shift in therapeutic development.
  • This approach enhances efficiency and specificity in designing novel drugs by leveraging the immune system.