Related Experiment Video
Updated: May 14, 2026
07:31
Nitropeptide Profiling and Identification Illustrated by Angiotensin II
Published on: June 16, 2019
Natriuretic peptide type B in burn intensive care
Andreas E Lindahl1, Mats Stridsberg, Folke Sjöberg
1Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
The Journal of Trauma and Acute Care Surgery
|February 22, 2013
Summary
N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in burn patients vary significantly but can predict organ dysfunction. High NT-proBNP in the first week after severe burns is an independent predictor of subsequent organ function and mortality.
Area of Science:
- Biomarkers in critical care
- Burn injury pathophysiology
- Prognostic indicators in trauma
Background:
- Plasma levels of NT-proBNP (N-terminal pro-B-type natriuretic peptide) indicate cardiac load but are also influenced by non-cardiac factors in critical illness.
- Previous studies on NT-proBNP as a marker of hydration and predictor of outcome in critically ill burn patients have yielded contradictory results.
Purpose of the Study:
- To measure plasma NT-proBNP levels in patients with severe burns.
- To correlate these levels with injury-related variables and organ dysfunction.
Main Methods:
- Fifty consecutive patients with >10% burn size were monitored for 2 weeks.
- Plasma NT-proBNP levels were analyzed in relation to burn size, age, body weight changes, C-reactive protein, and Sequential Organ Failure Assessment (SOFA) scores.
Main Results:
- NT-proBNP exhibited significant day-to-day and inter-patient variability.
- Daily body weight changes correlated with NT-proBNP only on Day 2; thereafter, NT-proBNP correlated with C-reactive protein and SOFA scores.
- Maximal NT-proBNP levels correlated with mortality and SOFA scores on Day 14, outperforming age and burn size as predictors.
Conclusions:
- NT-proBNP levels in burn patients show considerable variation but are linked to mortality, burn size, fluid shifts, and organ function.
- Elevated NT-proBNP levels between Days 3-8 independently predicted subsequent organ function up to 2 weeks post-injury.
- Maximum NT-proBNP levels correlated more strongly with length of stay and Day 14 organ function than age or burn size.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:27Transducer Mechanism: Enzyme-Linked Receptors
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
01:29Heart Failure II: Pathophysiology
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
01:18Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
01:17Hormonal Regulation of Blood Pressure
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction while...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction while...
01:22Acute Kidney Injury VI: Nursing Management
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...