Related Experiment Video
Updated: May 14, 2026
Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development
Published on: August 10, 2015
Organogenesis for kidney regeneration
1Project Laboratory for Kidney Regeneration, Department of Internal Medicine, Institute of DNA Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Purpose Of Review:
The kidney has an elaborate and complicated structure comprising several cell types. Damage or destruction of the kidney thus necessitates reconstruction of all the component cell types to regenerate a functional three-dimensional renal structure. Therefore, despite all the recent advances in our understanding and technical approaches to stem cell and developmental biology, the anatomical complexity of the renal system makes de-novo kidney regeneration the most difficult challenge for organ regenerative therapy.
Recent Findings:
To build a transplantable neo-kidney, some investigators propose using organogenesis. We suggest the metanephros of the developing kidney and blastocyst complementation can potentially generate a whole kidney with the required three-dimensional structure and renal function to produce urine and erythropoietin. In addition, some researchers are investigating the in-vitro differentiation of pluripotent stem cells into mature renal cells for in-vivo use.
Summary:
We review the current challenges to making a transplantable neo-kidney using stem cells.
Related Concept Videos
01:45Kidney Structure
01:24Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
01:29Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration
01:28Kidney Transplant I: Introduction
01:13Introduction to Urinary System
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
01:12Internal Anatomy of the Kidney
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...