Venostasis test as a method of choice to evaluate blood fibrinolytic capacity during third molar surgery

The aim of our research was to evaluate the fibrinolytic capacity during oral surgical interventions - operative extraction of semi-impacted third molars having caused blood fibrinolysis activity. With the intention of establishing the condition of the blood vessels' endothelium before oral surgical interventions, the influence of surgical procedures upon the endothelium, and the response of the endothelium after interventions, the venostasis test (venous stasis) was conducted in all the subjects. This test measures the global fibrinolytic activity of the plasma, caused by anoxia. In order to realize the aim, the first blood sample was taken before the beginning of the test, and then the indicated oral surgical intervention was performed. Immediately after the completion of the surgery, the venostasis test was carried out, lasting for five minutes, and right after the test a second sample of blood was taken. Using the method of fibrin plates, the level of the activators and inhibitors of the plasminogen was established afterwards. The average values of the pro activators and inhibitors of fibrinolysis from the venostasis test, in all subjects, showed increased values compared to the same ones in the control group, in all researched relations. Statistically, a significant difference was established after interventions were performed. These findings support the fact of possible damage to the blood vessels' endothelium and a change of the fibrinolytic capacity in the perioperative period of third molar surgery.