Depression among mothers of high-risk infants discharged from a neonatal intensive care unit
Related Experiment Video
Updated: May 14, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Thomas F Northrup1, Patricia W Evans, Angela L Stotts
1Department of Family and Community Medicine at University of Texas Medical School at Houston, Houston, TX, USA. Thomas.F.Northrup@uth.tmc.edu
Purpose:
This study investigated potential associations between maternal depression and specific infant health conditions, smoking, and socioeconomic characteristics among mothers of high-risk infants during medical follow-up visits.
Study Design And Methods:
Cross-sectional self-report, and interview data were collected from 114 mothers of high-risk infants previously discharged from a neonatal intensive care unit. Mothers were assessed at a postdischarge clinic visit.
Results:
Prevalence rates for a Center for Epidemiological Studies-Depression Scale score ≥ 16) suggestive of a depressive disorder exceeded 20% at all time points for this sample of predominantly low-income, minority-race mothers. A greater number of mothers who had infants with a highly visible illness (e.g., surgical necrotizing enterocolitis) were depressed. Depression was also associated with the presence of a household smoker, younger age, and less education and income.
Clinical Implications:
Given the prevalence rates, routine screening for postpartum depression in mothers of high-risk infants is imperative, with particular attention to the infant's health, smoking, and socioeconomic variables.
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