Related Experiment Video

Updated: May 14, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

Left ventricular diastolic dysfunction is associated with impaired baroreflex at rest and during orthostatic stress

K Makowski1, G Gielerak, E Kramarz

  • 1Military Institute of Medicine, Cardiology Department, Warsaw, Poland. karol.makowski7@gmail.com

Journal of Human Hypertension
|February 22, 2013
PubMed

Insights

Hypertension patients with left ventricular hypertrophy (LVH+) show impaired diastolic function and baroreflex sensitivity (BRS). Treatment improved both, linking diastolic function to better BRS during rest and orthostatic stress.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Cardiovascular Physiology

Background:

  • Left ventricular hypertrophy (LVH) is common in hypertensive patients and can affect cardiac function.
  • Baroreflex sensitivity (BRS) plays a crucial role in cardiovascular regulation, especially during stress.
  • The interplay between LV diastolic function and BRS in hypertensive patients with LVH is not fully understood.

Purpose of the Study:

  • To investigate the relationship between left ventricular (LV) diastolic function and spontaneous BRS.
  • To assess changes in diastolic function and BRS in hypertensive patients with LVH+ during long-term pharmacological treatment.
  • To identify independent predictors of BRS during orthostatic stress in this patient group.

Main Methods:

  • Prospective follow-up study involving 24 hypertensive patients with LVH+.
  • Evaluation of LV structure and function, and BRS using tilt testing.
  • Comparison with 25 healthy controls and 25 hypertensive patients without LVH (LVH-).
  • Assessment of clinical status, diastolic function, and BRS at 6 and 18 months during telmisartan-based treatment.

Main Results:

  • LVH+ patients exhibited significantly altered diastolic function and decreased BRS compared to controls and LVH- patients.
  • Favorable changes in diastolic function during 18-month follow-up were associated with improved BRS at rest and during tilting.
  • LV diastolic relaxation index (E'sept) and filling pressure surrogate (E/E'sept) were independently associated with low-frequency BRS during tilting.

Conclusions:

  • LV diastolic function indices are independently associated with BRS parameters at rest and during orthostatic stress in hypertensive patients with LVH+.
  • Pharmacological intervention can improve both LV diastolic function and BRS in this population.
  • These findings highlight the importance of assessing diastolic function in managing hypertensive patients with LVH for cardiovascular regulation.

More Related Videos

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...