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Related Experiment Video

Updated: May 14, 2026

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure
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Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Published on: February 12, 2018

Fabrication of a thin-layer solid optical tissue phantom by a spin-coating method: pilot study.

Yunjin Bae1, Taeyoon Son, Jihoon Park

  • 1Yonsei University, Department of Biomedical Engineering, 1 Yonseidae-gil, Wonju, Gangwon-do, 220-710, Republic of Korea.

Journal of Biomedical Optics
|February 22, 2013
PubMed
Summary

A novel spin-coating method fabricates thin-layer optical tissue phantoms (OTPs) with controllable epidermal thickness. This technique allows for precise control over phantom properties, enabling advanced optical imaging research.

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Area of Science:

  • Biomedical Optics
  • Materials Science
  • Optical Engineering

Background:

  • Solid optical tissue phantoms (OTPs) are crucial tools in biomedical optics research.
  • Existing methods may lack precise control over thin-film phantom properties.

Purpose of the Study:

  • To introduce and validate a spin-coating method (SCM) for fabricating thin-layer solid OTPs (TSOTPs) with epidermal thickness.
  • To investigate the influence of fabrication parameters on TSOTP thickness and optical properties.

Main Methods:

  • TSOTPs were fabricated using SCM by varying spin speed (250-2500 rpm), absorber concentration (0.2%-1.0%), and number of layers.
  • Thickness and absorption coefficients were measured to analyze fabrication parameter effects.

Main Results:

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Last Updated: May 14, 2026

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  • Homogeneous TSOTP thicknesses were achieved, ranging from 5.1±0.17 μm to 65±0.28 μm, controlled by spin speed and layer count.
  • Absorption coefficients increased exponentially with absorber concentration (R2≥0.98).
  • Multilayer TSOTP thickness correlated strongly with spin speed (R2≥0.95).

Conclusions:

  • SCM offers precise control over TSOTP thickness and optical properties for diverse applications.
  • The method is suitable for creating homogeneous thin-film phantoms with tunable characteristics.
  • A double-layer phantom demonstrated the practical feasibility of SCM for complex optical models.