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Updated: May 14, 2026

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
Published on: October 13, 2018
A method to determine the likelihood of transition to puberty in a heterogeneous prepubertal age group
James Frane1, George M Bright, Peter A Lee
1Penn State College of Medicine, Hershey, PA, USA. plee@psu.edu
Abstract:
A model based on pubertal status and age in normal healthy children that can be used to estimate the probability that a given child will enter or progress through puberty in a given period is presented. This model could also be used to estimate the proportion of children who would be expected to have changes in their pubertal status over a given period, for example, in an interventional trial of growth promoting agents.
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