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Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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Published on: August 28, 2015

Macroporous structures based on biodegradable polymers--candidates for biomedical application.

Bogdan C Simionescu1, Andrei Neamtu, Ciprian Balhui

  • 1Department of Natural and Synthetic Polymers, Gh. Asachi Technical University of Iasi, 700050 Iasi, Romania.

Journal of Biomedical Materials Research. Part A
|February 22, 2013
PubMed
Summary
This summary is machine-generated.

New hybrid cryogels combining natural polymers and poly(ε-caprolactone) were developed. These macroporous materials exhibit excellent swelling, mechanical stability, and proven biocompatibility for biomedical applications.

Keywords:
atelocollagenbiocompatible materialscryogelshyaluronan, poly(ε-caprolactone)

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Natural polymers like atelocollagen and hyaluronic acid derivatives offer biocompatibility.
  • Synthetic polyesters such as poly(ε-caprolactone) provide tunable mechanical properties.
  • Hybrid materials can combine the advantages of both natural and synthetic components.

Purpose of the Study:

  • To develop novel hybrid cryogels using atelocollagen and poly(ε-caprolactone).
  • To investigate the impact of preparation conditions on cryogel properties.
  • To evaluate the swelling, mechanical, and hemocompatibility of the developed cryogels for biomedical use.

Main Methods:

  • Cryogenic treatment and freeze-drying were employed for cryogel fabrication.
  • Differential scanning calorimetry (DSC), FTIR, and ESEM/SEM were used for material characterization.
  • In vitro swelling, hemocompatibility assays, and in vivo tolerance tests were performed.

Main Results:

  • Uniform, interconnected macroporous structures with porosity up to 95% and pore sizes of 83-260 μm were achieved.
  • The cryogels demonstrated elasticity, mechanical stability, and rapid swelling kinetics.
  • In vitro hemolysis ratios were below 0.5%, and in vivo tests confirmed excellent biocompatibility.

Conclusions:

  • Successfully developed novel hybrid cryogels from natural polymers and poly(ε-caprolactone).
  • Optimized preparation conditions led to materials with desirable porous morphology and mechanical properties.
  • The developed cryogels show significant promise for various biomedical applications due to their excellent hemocompatibility and biocompatibility.