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Related Experiment Video

Updated: May 14, 2026

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice
08:02

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice

Published on: October 19, 2013

Neonatal hyperoxia: effects on nephrogenesis and long-term glomerular structure.

Megan R Sutherland1, Megan O'Reilly, Kelly Kenna

  • 1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.

American Journal of Physiology. Renal Physiology
|February 22, 2013
PubMed
Summary

Early life exposure to high oxygen levels did not harm kidney development in mice. This study found no long-term negative effects on kidney structure or function in young or middle-aged mice.

Keywords:
nephrogenesispreterm birthrenal diseasesupplemental oxygen therapy

Related Experiment Videos

Last Updated: May 14, 2026

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice
08:02

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice

Published on: October 19, 2013

Area of Science:

  • Neonatal development
  • Renal physiology
  • Hyperoxia research

Background:

  • Nephrogenesis continues after birth in preterm neonates.
  • Extrauterine environmental factors can negatively impact renal development.
  • Supplemental oxygen therapy (hyperoxia) may induce oxidative stress in preterm infants.

Purpose of the Study:

  • To investigate the immediate and long-term effects of hyperoxia on renal development.
  • To assess impacts during the critical period of postnatal nephrogenesis.
  • To determine if early hyperoxia exposure causes lasting kidney damage.

Main Methods:

  • Newborn mice were exposed to normoxia (21% oxygen) or hyperoxia (65% oxygen) from birth to postnatal day 7.
  • Animals were maintained in room air until early adulthood (postnatal day 56) or middle age (10 months).
  • Kidney development, glomerular maturity, renal corpuscle size, and nephron number were assessed using stereology.

Main Results:

  • No immediate effects of hyperoxia on glomerular size or maturity at postnatal day 7.
  • In early adulthood, renal corpuscles were enlarged, but body weight, kidney weight/volume, and nephron number were unchanged.
  • By middle age, no significant differences in kidney weight/volume, nephron number, or renal corpuscle size were observed between groups.
  • Hyperoxia did not accelerate glomerulosclerosis in middle age.

Conclusions:

  • Early life exposure to hyperoxia does not cause overt long-term deleterious effects on glomerular structure in mice.
  • The transient enlargement of renal corpuscles in early adulthood resolved by middle age.
  • These findings suggest resilience of renal development to early hyperoxia in this model.