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Updated: May 14, 2026
07:51
Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
Relationship between maternal asthma, its severity and control and abortion
Lucie Blais1, Fatima-Zohra Kettani, Amélie Forget
1Faculté de pharmacie, Université de Montréal, CP 6128, succursale Centre-ville, Montréal, QC, Canada H3C 3J7. lucie.blais@umontreal.ca
Human Reproduction (Oxford, England)
|February 22, 2013
Summary
Pregnant women with asthma face a higher risk of spontaneous abortion, particularly if their asthma is uncontrolled. This study highlights the importance of asthma management during pregnancy to mitigate potential risks.
Area of Science:
- Reproductive Health
- Pulmonology
- Epidemiology
Background:
- Limited research exists on the association between asthma and abortion risks.
- One prior study indicated a modest increase in spontaneous abortion risk for women with severe asthma.
Purpose of the Study:
- To investigate the association between maternal asthma and the risk of spontaneous and induced abortions.
- To determine if asthma severity or control influences these risks.
Main Methods:
- A large cohort study linked administrative databases in Quebec, Canada (1992-2002).
- Included over 15,000 asthmatic and 34,000 non-asthmatic pregnant women.
- Used logistic regression to analyze abortion risks, adjusting for confounders.
Main Results:
- Maternal asthma was linked to a 41% increased risk of spontaneous abortion (OR=1.41).
- Uncontrolled asthma elevated spontaneous abortion risk by 26% and induced abortion risk by 11%.
- No significant association was found between asthma severity and abortion risk.
Conclusions:
- Uncontrolled asthma in pregnant women is associated with an increased risk of spontaneous abortion.
- While potential confounders exist, sensitivity analyses suggest they do not fully explain the findings.
- Further research may be needed to explore socio-economic factors and pregnancy-specific asthma control measures.
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