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Updated: May 14, 2026
Applying a Three-dimensional Uniaxial Mechanical Stimulation Bioreactor System to Induce Tenogenic Differentiation of Tendon-Derived Stem Cells
Published on: August 1, 2020
[Current situation and prospect of tenomodulin in tendon tissue engineering]
Cewen Guan1, Xing Lei, Yang Song
1Department of Orthopedics, the 1st Affiliated Hospital of Harbin Medical University, Harbin Heilongjiang, 150001, PR China.
Objective:
To review the latest researches of Tenomodulin in tendon tissue engineering, to predict the progress of research and application of Tenomodulin.
Methods:
The literature concerning Tenomodulin in tendon tissue engineering was collected and analyzed.
Results:
Tenomodulin is a type II transmembrane glycoprotein that can regulate growth of tendon and contains a C-terminal anti-angiogenic domain. The human Tenomodulin gene spans approximately 1360 bp and is mapped to Xq22.1. The expression of Tenomodulin is regulated by various biological factors, especially Scleraxis; and the nature and structure of scaffold material as well as the stain loading and cell passage, can modulate the expression of Tenomodulin.
Conclusion:
Tenomodulin, as relatively specific molecule makers for tendon and containing a C-terminal anti-angiogenic domain, is expected to play a significant role in tendon tissue engineering.
