Related Experiment Video
Updated: May 14, 2026

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
Published on: November 21, 2017
Hypohidrosis and hyperthermia during topiramate treatment in children
Faruk Incecik1, M Ozlem Hergüner, Sakir Altunbaşak
1Department of Pediatric Neurology, Cukurova University Faculty of Medicine, Adana, Turkey. fincecik@yahoo.com
Abstract:
Topiramate is one of the newer generation antiepileptic drugs with a beneficial clinical effect on various seizure types. In this study, we present the clinical findings of hypohidrosis and hyperthermia with topiramate in pediatric patients. The data were collected retrospectively on 173 patients diagnosed as epilepsy on topiramate treatment, and hypohidrosis-related symptoms induced by topiramate were found in 22 patients. Their mean age was 64.45 +/- 56.63 months. The mean duration of topiramate treatment was 7.09 +/- 2.46 months, and the mean dose was 5.37 +/- 1.75 mg/kg/day. All of the patients complained of hypohidrosis and hyperthermia. Six (27.2%) of them had facial flushing, 4 (18.1%) had heat sensation and only 1 (4.5%) had lethargy. Hypohidrosis-related symptoms resolved after discontinuation of the medication. In conclusion, children treated with topiramate should be cautioned regarding these potential adverse effects and advised to avoid its use during the hot summer season.
Related Concept Videos
Increased Body Temperature
Homeostatic Imbalances in Body Temperature
Methods of reducing fever
Pharmacological Methods of Reducing Fever:
Thermoregulation
Hyperthyroidism I: Introduction
Hyperthyroidism II: Pathophysiology

