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Updated: May 14, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
[Comparison of discriminative methods of hypoglycemic drugs by Raman spectroscopy]
Qun Gao1, Zhong-Hu Zhang, Feng Lu
1College of Pharmacy, Second Military Medical University, Shanghai 200433, China. gaoqun_0226@hotmail.com
Abstract:
In the present paper, four kinds of cluster analysis methods were used in rapid, non-destructive discrimination of hypoglycemic tablets by the Raman spectroscopy technology. Nine kinds of hypoglycemic tablets, including 48 samples, were determined using a Raman spectrometer. The sample data were pretreated with the methods of frequency range cutting, baseline correction, smoothing and vector normalization, then were analyzed by K-means, hierachical cluster, self-organizing maps (SOM) and PCA-SOM respectively. The results demonstrated that SOM was better than K-means and hierachical cluster, and it provided the best discrimination when combined with PCA. The research offers a new approach to the rapid discrimination of different kinds of hypoglycemic tablets.
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