Spatial relationship between Ph and normal chromosome 22 at somatic metaphase in chronic myelogenous leukemia

The spatial distances between the Ph and the normal chromosome 22 in bone marrow are compared with the distances between the two normal chromosome 22s in peripheral blood. No significant differences between these two distances were found in two different tissues. The present findings indicate that length does not affect the spatial relationship between the homologous chromosomes in the nucleus, as previously postulated.