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Updated: May 14, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Cancer cell cytotoxicity of cyclometalated compounds obtained with osmium(II) complexes
Bastien Boff1, Christian Gaiddon, Michel Pfeffer
1Institut de Chimie, UMR 7177 du CNRS, Université de Strasbourg, 4, rue Blaise Pascal, 67000 Strasbourg, France.
Abstract:
A library of 29 organoosmium compounds has been built up with known and novel cyclometalated compounds obtained with C-N, N(∧)C(∧)N, and C(∧)N(∧)N ligands. All compounds have been tested for their in vitro cytotoxic properties against A172, a tumor cell line derived from a human glioblastoma, this affording a contrasted picture of the activities of the compounds gathered in this study. Some compounds displayed good to excellent activities, some of them showing IC50 in the nanomolar range. The level of activity was tentatively correlated to several physicochemical properties of the compounds such as their E(0)1/2(Os(III/II)) redox potential and their lipophilicity (log Po/w). A parallel with related ruthenium derivatives was tentatively proposed.
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