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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: May 14, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
05:06

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

Published on: October 24, 2015

Mouse models for liver cancer.

Latifa Bakiri1, Erwin F Wagner

  • 1Genes, Development and Disease Group, F-BBVA Cancer Cell Biology Programme, Spanish National Cancer Research Centre, Melchor Fernandez Almagro 3, 28029 Madrid, Spain. lbakiri@cnio.es

Molecular Oncology
|February 23, 2013
PubMed
Summary
This summary is machine-generated.

Hepatocellular carcinoma (HCC) is a deadly liver cancer with limited treatments. Genetically engineered mouse models (GEMMs) are crucial for understanding HCC and developing new therapies.

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Murine Bioluminescent Hepatic Tumour Model
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Last Updated: May 14, 2026

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Murine Bioluminescent Hepatic Tumour Model
05:23

Murine Bioluminescent Hepatic Tumour Model

Published on: July 17, 2010

Area of Science:

  • Oncology
  • Genetics
  • Translational Medicine

Background:

  • Hepatocellular carcinoma (HCC) is a prevalent and deadly liver cancer with increasing incidence.
  • Current therapeutic options for HCC are limited, leading to poor patient survival rates.
  • Metabolic diseases are increasingly contributing to HCC development worldwide.

Purpose of the Study:

  • To review the current state of hepatocellular carcinoma (HCC) modeling in mice.
  • To highlight the successes and challenges in using genetically engineered mouse models (GEMMs) for HCC research.
  • To identify future opportunities for mechanism-based therapy development in HCC.

Main Methods:

  • Review of technological advances in generating genetically engineered mouse models (GEMMs).
  • Analysis of GEMMs for mimicking human cancer alterations and conducting intervention studies.
  • Evaluation of GEMMs for assessing gene networks in tumor establishment, progression, and maintenance.

Main Results:

  • GEMMs allow for molecular and cellular manipulations not possible in human patients.
  • GEMMs have significantly advanced the understanding of HCC's complex biology.
  • GEMMs offer substantial potential for developing novel, mechanism-based therapies for HCC.

Conclusions:

  • Genetically engineered mouse models (GEMMs) are invaluable tools for HCC research.
  • Continued development and application of GEMMs are essential for improving HCC prevention, diagnosis, and treatment.
  • Addressing challenges and exploring future opportunities in HCC modeling will accelerate therapeutic breakthroughs.