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Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids
11:01

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Published on: September 25, 2016

Nutritional catch-up growth.

Galia Gat-Yablonski1, Rakefet Pando, Moshe Phillip

  • 1The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Children's Diabetes, Schneider Children's Medical Center of Israel, Petah Tikva, Israel. galiagy@post.tau.ac.il

World Review of Nutrition and Dietetics
|February 23, 2013
PubMed
Summary
This summary is machine-generated.

Malnutrition causes stunted growth, but catch-up growth can be incomplete. This study reveals how nutritional changes affect growth plate gene expression via transcription factors, epigenetics, and microRNAs.

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Last Updated: May 14, 2026

Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids
11:01

Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids

Published on: September 25, 2016

Area of Science:

  • Pediatric Endocrinology
  • Nutritional Science
  • Molecular Biology

Background:

  • Malnutrition is a primary cause of stunted growth globally, particularly in developing nations.
  • While nutritional rehabilitation often leads to catch-up growth, deficits can persist.
  • Understanding the regulatory mechanisms of growth during nutritional recovery is crucial.

Purpose of the Study:

  • To investigate the molecular mechanisms underlying nutrition-induced catch-up growth.
  • To identify key regulatory factors in the growth plate affected by nutritional status.

Main Methods:

  • Established a rat model of food restriction followed by refeeding.
  • Measured serum levels of leptin and insulin-like growth factor-1.
  • Analyzed gene expression in the growth plate, including transcription factors and microRNAs.

Main Results:

  • Food restriction decreased leptin and IGF-1 levels, which recovered upon refeeding.
  • Hypoxia-inducible factor-1 and global gene expression were altered by food restriction.
  • Reduced miR-140 levels led to increased SIRT1 expression, suggesting epigenetic involvement.

Conclusions:

  • Nutritional status influences growth plate development through transcription factors, epigenetic modifications, and microRNAs.
  • These regulatory pathways offer potential targets for treating growth disorders.
  • Further research is needed to understand how nutritional status is sensed at a molecular level.