Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
Positive Symptoms Schizophrenia: Hallucinations and Delusions01:26

Positive Symptoms Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
Personality Disorders: Paranoid and Schizoid01:22

Personality Disorders: Paranoid and Schizoid

Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
Paranoid personality disorder is...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of the Next <i>DSM</i>-Learnings From the <i>DSM-5</i> Experience.

The American journal of psychiatry·2026
Same author

Negative symptoms in schizophrenia: Methodological challenges and emerging solutions for outcome measurement.

Neuroscience applied·2026
Same author

The increasing incomprehensibility of medical research for clinicians.

Asian journal of psychiatry·2026
Same author

Cerebellum-Cerebrum Dynamics During Gaze Processing in Schizophrenia: Evidence for Social-Cognitive Modulation and Associations with Social Functioning Across Independent Samples.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

Changing your perspective on fatal outcomes in clozapine-treated patients. They do not die of agranulocytosis.

Asian journal of psychiatry·2026
Same author

Negative symptoms of schizophrenia demonstrate measurement bias across sociodemographic variables.

Schizophrenia research·2026
Same journal

Dysexecutive Behavior in First-Episode Schizophrenia.

Clinical schizophrenia & related psychoses·2023
Same journal

Antipsychotic Adherence Intervention for Veterans over Forty with Schizophrenia: Results of a Pilot Study.

Clinical schizophrenia & related psychoses·2019
Same journal

Special Phenomena in Rorschach Protocols in Patients Diagnosed with Schizophrenia.

Clinical schizophrenia & related psychoses·2019
Same journal

'Something wasn't quite right': a novel phenomenological analysis of internet discussion posts detailing initial awareness of psychosis.

Clinical schizophrenia & related psychoses·2019
Same journal

Clinical News.

Clinical schizophrenia & related psychoses·2019
Same journal

Letters to the Editor.

Clinical schizophrenia & related psychoses·2019
See all related articles

Related Experiment Video

Updated: May 14, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Negative symptoms in schizophrenia.

Nash N Boutros1, Armida Mucci2, Vaibhav Diwadkar3

  • 1Department of Psychiatry and Neurosciences, University of Missouri in Kansas City (UMKC), Kansas City, MO.

Clinical Schizophrenia & Related Psychoses
|February 23, 2013
PubMed
Summary
This summary is machine-generated.

Deficit schizophrenia, characterized by negative symptoms, shows distinct electrophysiological patterns. Research suggests this subgroup may represent a separate disease entity from general schizophrenia.

Keywords:
Deficit SyndromeElectroencephalography (EEG)Evoked Potentials (EPs)Negative SymptomsPolysomnography (PSG)Schizophrenia

More Related Videos

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Related Experiment Videos

Last Updated: May 14, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Psychology

Background:

  • Schizophrenia exhibits significant clinical heterogeneity, complicating research.
  • Deficit schizophrenia (DS) is proposed as a distinct subtype characterized by persistent negative symptoms.
  • Electrophysiological correlates of negative symptoms in schizophrenia are under investigation, with limited focus on DS.

Purpose of the Study:

  • To review and synthesize electrophysiological findings related to negative symptoms and the deficit syndrome in schizophrenia.
  • To explore whether electrophysiological data support DS as a separate disease entity.

Main Methods:

  • Systematic literature search of PubMed and MEDLINE for studies on negative symptoms or DS using electroencephalography (EEG), evoked potentials (EPs), or polysomnography (PSG).
  • Analysis of trends in spectral EEG, sleep studies, and other electrophysiological abnormalities.

Main Results:

  • Increased slow wave activity during wakefulness and decreased slow wave sleep are associated with negative symptoms.
  • Reduced alpha activity and other abnormalities like sensory gating deficits and P300 attenuation are also linked to negative symptoms.
  • Two studies specifically examining DS electrophysiology suggest it may be a distinct entity.

Conclusions:

  • Electrophysiological findings, particularly altered brain activity patterns, provide evidence supporting deficit schizophrenia as a potentially separate disease entity.
  • Further research into the electrophysiology of DS is warranted to clarify its unique pathological mechanisms.