Asymptotic analysis of the Poisson-Boltzmann equation in biological membrane channels

The Poisson-Boltzmann equation has been increasingly used for the description of biomolecular systems in order to derive their electrostatic properties. We here consider a domain consisting of two living cells which communicate through a system of proteins which assemble at specific membrane areas building microchannels called gap junctions. We describe the asymptotic behavior of the solution of the Poisson-Boltzmann equation posed in this domain. Using Γ-convergence tools, we derive some electrostatic properties of the biological membrane with respect to a vanishing parameter which is simultaneously associated to the membrane thinness, to the diameter of the gap junction microchannels and to the Debye length parameter which characterizes the spatial scale electrostatic interactions between particles within the gap junctions.