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Related Experiment Video

Updated: May 14, 2026

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Published on: March 14, 2020

TGR5 in cholangiocytes.

Verena Keitel¹, Dieter Häussinger

¹Clinic for Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Düsseldorf, Germany.

Current Opinion in Gastroenterology

|February 23, 2013

Summary

This summary is machine-generated.

TGR5 (Gpbar-1) is a receptor in liver cells that shows protective functions in biliary diseases. Further research is needed to explore its therapeutic potential for conditions like primary biliary cirrhosis.

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Area of Science:

Hepatology
Gastroenterology
Cell Biology

Background:

TGR5 (Gpbar-1) is a G protein-coupled receptor with emerging therapeutic relevance.
Highest TGR5 expression in the liver is observed in biliary epithelial cells (cholangiocytes).

Purpose of the Study:

To review the function of TGR5 in cholangiocytes.
To evaluate the potential role of TGR5 in biliary diseases.

Main Methods:

Review of recent human and animal studies.
Analysis of TGR5 localization and effects in cholangiocytes.

Main Results:

TGR5 is localized to the primary cilium and apical membrane of cholangiocytes.
TGR5 activation demonstrates secretory, proliferative, and antiapoptotic effects in cholangiocytes.
Evidence suggests therapeutic potential for TGR5 in primary biliary cirrhosis, but not primary sclerosing cholangitis.

Conclusions:

TGR5 exhibits protective functions within cholangiocytes.
Further investigation is required to establish the therapeutic utility of TGR5 agonists and antagonists in managing biliary diseases.