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Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
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The genetic basis of schizophrenia is strongly supported by family and twin studies.
Sex-linked Disorders01:43

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Human Genetics01:28

Human Genetics

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Genomic Imprinting and Inheritance

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Behavioral Genetics and Its Designs

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Related Experiment Video

Updated: May 14, 2026

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
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A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

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Genetic causes of developmental disorders.

Jacob A S Vorstman1, Roel A Ophoff

  • 1Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands. j.a.s.vorstman@umcutrecht.nl

Current Opinion in Neurology
|February 23, 2013
PubMed
Summary

Recent genetic advances reveal numerous causes for developmental disorders like intellectual disability, autism, and attention deficit hyperactivity disorder (ADHD). Understanding these genetic factors and shared neurobiological pathways is key for future treatments.

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Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
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Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology

Background:

  • Developmental disorders, including intellectual disability, autism, and attention deficit hyperactivity disorder (ADHD), are neuropsychiatric conditions originating in early childhood.
  • Currently, the specific causes for many of these disorders remain unidentified.
  • Significant progress in genetic research over the last five years has led to the identification of specific genetic etiologies.

Purpose of the Study:

  • To review recent findings in the genetic causes of developmental disorders.
  • To discuss the implications of these genetic discoveries for understanding the etiology of these conditions.

Main Methods:

  • Review of recent genetic studies and findings.
  • Analysis of identified genetic variants, including structural variants and those found through sequencing.
  • Functional studies of disease-associated genes.

Main Results:

  • Identification of a growing number of novel recurrent structural variants associated with intellectual disability, autism, and ADHD.
  • Sequencing approaches have revealed the involvement of a large number of genes in these disorders.
  • Genetic studies show significant heterogeneity for autism and ADHD, similar to intellectual disability.

Conclusions:

  • Many identified risk variants exhibit incomplete penetrance, suggesting the involvement of additional genetic or environmental factors.
  • Despite numerous causative genes, functional studies highlight convergence into a limited number of neurobiological pathways.
  • Elucidating these shared biological mechanisms is essential for developing targeted therapeutic interventions.