Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Photonic crystal band edge coupled enhanced fluorescence from magneto-plasmonic cryosoret nano-assemblies for ultra-sensitive detection.

APL materials·2026
Same author

Ultrasensitive non-enzymatic protein detection using proximity immunoassay with photonic resonator absorption microscopy.

Npj biosensing·2026
Same author

Zuojin Pill ameliorates depression with gastrointestinal dysfunction via Parabacteroides distasonis.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

Selective capture and digital counting of intact HIV pseudovirus using designer DNA nets, tethered motion, and photonic resonator interferometric scattering microscopy.

APL bioengineering·2026
Same author

A 1.5D Photonic Crystal Interface for Prism-Free, Near-Normal, Low-Background Photoluminescence.

Nano letters·2026
Same author

Laser-damage risk assessment with extreme-event statistics.

Optics express·2026
Same journal

Microfluidic rare cell analysis beyond counting: workflow design from enrichment to multi-omics.

Lab on a chip·2026
Same journal

A sperm racetrack to separate sperm by swim speed.

Lab on a chip·2026
Same journal

Controlled encapsulation and droplet size prediction in two-step microfluidic double emulsions.

Lab on a chip·2026
Same journal

A particulate blood-mimicking fluid with physiological biconcave geometry for microscale hemorheology.

Lab on a chip·2026
Same journal

Multicellular sensor arrays fabricated by capillary stamping for pattern-based odor discrimination.

Lab on a chip·2026
Same journal

A real-time microfluidic surveillance system for multiplex detection of heavy metal contamination in wastewater.

Lab on a chip·2026
See all related articles

Related Experiment Video

Updated: May 14, 2026

Laser-Induced Fluorescence Emission (L.I.F.E.) as Novel Non-Invasive Tool for In-Situ Measurements of Biomarkers in Cryospheric Habitats
13:38

Laser-Induced Fluorescence Emission (L.I.F.E.) as Novel Non-Invasive Tool for In-Situ Measurements of Biomarkers in Cryospheric Habitats

Published on: October 26, 2019

External cavity laser biosensor.

Chun Ge1, Meng Lu, Sherine George

  • 1Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

Lab on a Chip
|February 23, 2013
PubMed
Summary
This summary is machine-generated.

This study introduces a novel label-free optical biosensor using a tunable photonic crystal. It achieves high sensitivity and dynamic range by integrating stimulated emission for enhanced performance.

More Related Videos

Optical Detection of E. coli Bacteria by Mesoporous Silicon Biosensors
07:22

Optical Detection of E. coli Bacteria by Mesoporous Silicon Biosensors

Published on: November 20, 2013

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
09:35

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents

Published on: May 1, 2012

Related Experiment Videos

Last Updated: May 14, 2026

Laser-Induced Fluorescence Emission (L.I.F.E.) as Novel Non-Invasive Tool for In-Situ Measurements of Biomarkers in Cryospheric Habitats
13:38

Laser-Induced Fluorescence Emission (L.I.F.E.) as Novel Non-Invasive Tool for In-Situ Measurements of Biomarkers in Cryospheric Habitats

Published on: October 26, 2019

Optical Detection of E. coli Bacteria by Mesoporous Silicon Biosensors
07:22

Optical Detection of E. coli Bacteria by Mesoporous Silicon Biosensors

Published on: November 20, 2013

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
09:35

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents

Published on: May 1, 2012

Area of Science:

  • Photonics
  • Biotechnology
  • Materials Science

Background:

  • Passive optical resonator biosensors and laser-based biosensors have limitations in sensitivity and dynamic range.
  • Existing biosensing technologies often require complex instrumentation or labels for detection.

Purpose of the Study:

  • To develop a novel label-free optical biosensor with high quality factor, sensitivity, and dynamic range.
  • To utilize a tunable photonic crystal resonant reflector as an external cavity laser mirror.
  • To demonstrate biomolecule-induced tuning of a continuous-wave laser wavelength.

Main Methods:

  • Fabrication of an inexpensive plastic photonic crystal resonant reflector.
  • Integration of the photonic crystal with a semiconductor optical amplifier for external cavity laser gain.
  • Noncontact, normally incident illumination and back-reflection for detection.
  • Demonstration of single-mode laser wavelength tuning via biomolecular adsorption.

Main Results:

  • Achieved a high quality factor through stimulated emission.
  • Demonstrated high sensitivity and large dynamic range in the label-free biosensor.
  • Successfully tuned the continuous-wave laser wavelength by adsorbing biomolecules.
  • Showcased a simple detection instrument with noncontact illumination.

Conclusions:

  • The developed photonic crystal laser biosensor offers significant advantages over previous passive optical resonator and laser-based biosensors.
  • The device's design, incorporating external optical gain separate from the transducer, enhances performance.
  • This technology represents a promising advancement for sensitive and label-free biomolecular detection.