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Is there an association between perinatal complications and attention-deficit/hyperactivity disorder-inattentive type

Carla Ruffoni Ketzer1, Carolina Gallois, Ana Luiza Martinez

  • 1ADHD Outpatient Program, Universidade Federal do Rio Grande do Sul, Brazil.

Revista Brasileira De Psiquiatria (Sao Paulo, Brazil : 1999)
|February 23, 2013
PubMed

Insights

Prenatal, delivery, and early postnatal complications (PDPC) are linked to a higher risk of attention deficit/hyperactivity disorder, predominantly inattentive type (ADHD-I). These findings highlight the importance of addressing preventable perinatal factors for public mental health.

Area of Science:

  • Neurodevelopmental Disorders
  • Perinatal Health
  • Child Psychology

Background:

  • Attention Deficit/Hyperactivity Disorder (ADHD), particularly the inattentive subtype (ADHD-I), affects a significant number of children and adolescents.
  • Previous research suggests a link between perinatal factors and ADHD, but specific associations with ADHD-I require further investigation.

Purpose of the Study:

  • To examine the association between prenatal, delivery, and early postnatal complications (PDPC) and ADHD-I.
  • To determine if maternal complications during pregnancy and early life influence the risk of developing ADHD-I in offspring.

Main Methods:

  • A case-control study design was employed, including 124 children and adolescents diagnosed with ADHD-I and 124 matched controls.
  • Participants were recruited from both non-referred and clinical samples, aged 6-17 years.
  • Data on PDPC and potential confounders were collected through direct interviews with biological mothers.

Main Results:

  • A statistically significant association was found between a higher number of PDPC in mothers and an increased risk of ADHD-I in their children (p = 0.005; OR = 1.25; 95% CI: 1.1-1.5).
  • The findings indicate that maternal complications during the perinatal period elevate the likelihood of ADHD-I.

Conclusions:

  • This study reinforces the connection between perinatal factors and ADHD, specifically for the inattentive subtype.
  • Given that some PDPC are preventable, these findings have significant implications for public mental health policies and interventions aimed at reducing ADHD-I risk.
Abstract

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