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Updated: May 14, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
A case-control association study between Obsessive-Compulsive Disorder (OCD) and the MCP-1 -2518G/A polymorphism in a
Xinhua Zhang1, Yingying Yin, Shiguo Liu
1Department of Pychology and Psychiatry, Medical College, Qingdao University, Qingdao, China.
Objective:
To investigate the association between Obsessive-Compulsive Disorder (OCD) and a functional polymorphism of MCP-1 in the Chinese Han population.
Method:
We genotyped and performed a case-control association analysis of the MCP-1 -2518G/A polymorphism in 200 OCD patients and 294 healthy control subjects.
Results:
There was no significant difference in MCP-1 -2518G/A genotypic and allelic frequencies between OCD cases and controls (x² = 1.123, df = 2, P = 0.57 by genotype; x² = 0.802, df = 1, P = 0.37 by allele).
Conclusions:
Our results indicated that MCP-1 -2518G/A may not play a major role in the genetic predisposition of the Chinese Han population to OCD. However, further studies using a larger number of subjects are required to obtain a clear conclusion.
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