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Related Concept Videos

Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

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Updated: May 14, 2026

Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model
05:52

Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model

Published on: December 8, 2023

Mycobacterium tuberculosis septic shock.

Shravan Kethireddy1, R Bruce Light2, Yazdan Mirzanejad3

  • 1Section of Critical Care Medicine, University of Manitoba, Winnipeg, MB, Canada.

Chest
|February 23, 2013
PubMed
Summary
This summary is machine-generated.

Septic shock from Mycobacterium tuberculosis (MTB) has high mortality, similar to bacterial septic shock. Early appropriate antimicrobial therapy is crucial for improving survival in MTB septic shock patients.

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Preparation of Mycobacterium tuberculosis Culture Filtrate to Understand TB Pathogenesis
07:32

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Published on: March 28, 2025

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Microbiology

Background:

  • Septic shock caused by Mycobacterium tuberculosis (MTB) is a rare but recognized clinical condition.
  • This study compares the clinical features, risk factors, and survival of patients with MTB septic shock to those with other bacterial septic shock.

Purpose of the Study:

  • To describe the unique clinical characteristics of MTB septic shock.
  • To identify epidemiologic risk factors associated with MTB septic shock.
  • To compare survival outcomes between MTB septic shock and bacterial septic shock.

Main Methods:

  • A retrospective nested cohort study was performed.
  • Data were extracted from a trinational database of 8,670 patients with septic shock between 1996 and 2007.
  • 53 patients diagnosed with MTB septic shock were compared to 5,419 patients with septic shock from common bacterial pathogens.

Main Results:

  • MTB septic shock had a significantly higher in-hospital mortality rate (79.2%) compared to bacterial septic shock (49.7%).
  • Most MTB septic shock cases involved respiratory tract issues, and 55% showed disseminated extrapulmonary involvement.
  • Early appropriate antimicrobial therapy (within 24 hours) was associated with improved survival (54.5%) compared to delayed therapy (4.8%).

Conclusions:

  • MTB septic shock exhibits clinical behavior and mortality patterns similar to bacterial septic shock.
  • Prompt and appropriate antimicrobial treatment is critical for reducing mortality in patients with MTB septic shock.