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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.

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Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
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Proteomics as a tool for understanding schizophrenia.

Daniel Martins-de-Souza1

  • 1Max Planck Institute of Psychiatry, Munich, Germany and Lab. de Neurociências (LIM-27), Inst. Psiquiatria, Fac. de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology
|February 23, 2013
PubMed
Summary
This summary is machine-generated.

Proteomics reveals altered protein expression in schizophrenia brains, impacting energy metabolism, myelin, and cytoskeleton. These findings offer insights into disease mechanisms and potential therapeutic targets.

Keywords:
CalciumEnergy metabolismMyelinOligodendrocytesProteomicsSchizophrenia

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JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

Area of Science:

  • Neuroscience
  • Biochemistry
  • Genetics

Background:

  • Schizophrenia is a complex, multifactorial disorder influenced by genetic and environmental factors.
  • Altered gene and protein expression during neurodevelopment contributes to schizophrenia.
  • Proteomics offers a powerful approach to identify biomarkers and understand disease mechanisms.

Purpose of the Study:

  • To investigate proteomic alterations in distinct brain regions of schizophrenia patients.
  • To identify proteins and pathways dysregulated in schizophrenia.
  • To explore potential therapeutic targets for schizophrenia treatment.

Main Methods:

  • Proteomic analysis of post-mortem brain tissue from schizophrenia patients and controls.
  • Comparison of protein expression across five distinct brain regions.
  • Identification of differentially expressed proteins related to disease pathology.

Main Results:

  • Proteins involved in energy metabolism were significantly altered.
  • Dysregulation of calcium homeostasis proteins was observed.
  • Alterations in myelinization and cytoskeleton-associated proteins were recurrent findings.

Conclusions:

  • Proteomic findings highlight compromised pathways in schizophrenia, including energy metabolism, calcium signaling, and structural components.
  • These differentially expressed proteins represent potential biomarkers for schizophrenia diagnosis and prognosis.
  • The study suggests novel avenues for understanding schizophrenia pathobiology and developing targeted therapies.