Related Experiment Video
Updated: May 14, 2026

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
StuI polymorphism on the androgen receptor gene is associated with recurrent spontaneous abortion
Tahere Jahaninejad1, Nasrin Ghasemi, Seyyed Mehdi Kalantar
1Medical Genetics Department, Research and Clinical Centre for Infertility, Yazd Shahid Sadoughi Medical Sciences University and Health Services, Yazd, Iran. N479g@yahoo.co.uk
Purpose:
This is a case- control study to determine whether G1733A polymorphism of androgen receptor gene is associated with an increased risk for recurrent spontaneous abortion (RSA).
Method:
A total of 85 women with at least two recurrent spontaneous abortion before 20th week of gestation composed the study group. Subjects were genotyped by the polymerase chain reaction restriction fragment length polymorphism method.
Results:
The observed frequencies of GG, GA and AA genotypes of the G1733A polymorphism were 5.89 %, 82.35 % and 11.76 %, respectively, for the patient group and 71.76 %, 23.51 % and 4.71 %, respectively, for the control group. Allele frequencies of the G1733A polymorphism among patients and controls were 0.47 and 0.84, respectively, for the dominant allele (G) (wild type) and 0.53 and 0.16, respectively, for the A allele (mutant type).
Conclusions:
These results indicated that the androgen receptor G1733A polymorphism is strongly associated with increased risk for RSA.
More Related Videos
05:16Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
10:24A High Throughput in situ Hybridization Method to Characterize mRNA Expression Patterns in the Fetal Mouse Lower Urogenital Tract
Published on: August 19, 2011
Related Concept Videos
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Alternative RNA Splicing
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
RNA Splicing
Nondisjunction
Conservative Site-specific Recombination and Phase Variation
The recognition sites for Cre recombinase called LoxP...
Non-LTR Retrotransposons