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Updated: May 14, 2026

Intramyocardial Cell Delivery: Observations in Murine Hearts

Intramyocardial Cell Delivery: Observations in Murine Hearts

Published on: January 24, 2014

Does use of cell saver decrease the inflammatory response in cardiac surgery?

Maria A Prieto¹, Sara Guash, Jose C Mendez

¹Department of Anesthesiology, Hospital Universitario La Princesa, Madrid, Spain.

Asian Cardiovascular & Thoracic Annals

|February 23, 2013

Summary

This summary is machine-generated.

Cell salvage devices in cardiac surgery did not reduce inflammatory cytokine levels. Interleukin-6 and p40 levels were higher with cardiotomy suction, while interleukin-8 was higher with cell salvage, with similar clinical outcomes.

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Last Updated: May 14, 2026

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Published on: January 24, 2014

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

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Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Area of Science:

Cardiovascular Surgery
Immunology
Biomedical Engineering

Background:

The impact of cell-saver devices on the inflammatory response during cardiac surgery remains unclear.
This study investigated whether cell salvage could mitigate pro-inflammatory cytokine levels in patients undergoing cardiac procedures.

Purpose of the Study:

To evaluate the effect of cell salvage on plasma proinflammatory cytokine concentrations in patients undergoing cardiac surgery.
To compare inflammatory marker levels between cell salvage and control groups throughout the perioperative period.

Main Methods:

Prospective randomized controlled trial involving 57 patients undergoing first-time non-emergency cardiac surgery.
Blood samples collected at multiple perioperative time points for analysis of plasma proinflammatory cytokines using ELISA.
Comparison of cytokine levels (Interleukin-6, -8, -12 p40, Interferon-gamma) between cell salvage and cardiotomy suction blood.

Main Results:

Peak cytokine levels were observed 1 hour post-surgery.
Higher concentrations of Interleukin-12 p40 were found at 1 and 24 hours post-surgery.
Interleukin-6 and p40 were higher in cardiotomy suction blood (p=0.01), while Interleukin-8 was higher in cell-saver processed blood (p=0.03). No significant differences in Interleukin-1 or Interferon-gamma.

Conclusions:

Cell salvage in low-risk patients undergoing elective cardiac surgery does not appear to reduce the overall inflammatory response.
The study found specific differences in cytokine profiles depending on the blood processing method.
Clinical outcomes were comparable between the cell salvage and control groups.