Related Experiment Video
Updated: May 14, 2026

Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet
Published on: January 3, 2017
Evidence of clinically relevant efficacy for dietary supplements and nutraceuticals
Arrigo F G Cicero1, Claudio Borghi
1Medical and Surgical Science Department, University of Bologna, Via Albertoni 15 - Pad. 2, 40138, Bologna, Italy.
Abstract:
Beyond the well-known effects on blood pressure (BP) of the DASH and the Mediterranean diets, a large number of studies have investigated the possible a BP-lowering effect from different dietary supplements and nutraceuticals, mostly antioxidant agents with a high tolerability and safety profile. In particular, a relatively large body of evidence support the use of potassium, L-arginine, vitamin C, cocoa flavonoids, coenzyme Q10, controlled-release melatonin, and aged garlic extract. However there is a need for data about the long-term safety of a large part of these products. Moreover, further clinical research is advisable to identify between the available active nutraceuticals and those with the best cost-effectiveness and risk-benefit ratio for widespread use in a general population with low added cardiovascular risk related to uncomplicated hypertension.
Related Concept Videos
Clinically Relevant Drug Product Specifications: Methods of Establishment
Clinical Trials
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview
Drug Regulation
Dose-Response Relationship: Potency and Efficacy
Bioequivalence of Drugs: Drugs with Multiple Indications