Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

1.6K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
1.6K
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

1.8K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
1.8K
Narcolepsy01:07

Narcolepsy

453
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
453
Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

2.3K
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
2.3K
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

2.7K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.7K
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

468
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
468

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Muscle Strength, Balance, and Indoor Mobility in Oculopharyngeal Muscular Dystrophy: An Exploratory Canadian Multicenter Study.

Muscle & nerve·2026
Same author

Longitudinal Correlates of Psychological Demand in Working Adolescents: A Canadian Population-Based Exploratory Study.

Journal of occupational and environmental medicine·2026
Same author

Exploring the impact of myotonia on daily functioning in myotonic dystrophy: a patient-reported survey.

BMC neurology·2026
Same author

Gynecological and Obstetrical Issues Experienced by Women Diagnosed with Myotonic Dystrophy Type 1: A Scoping Review.

Journal of women's health (2002)·2026
Same author

Longitudinal Psychometric Properties of the Myotonic Dystrophy Health Index in a Large Multicenter Cohort of People Living With Myotonic Dystrophy Type 1.

Muscle & nerve·2026
Same author

Short-term course of the neuropsychological profile in myotonic dystrophy type 1: a 12-month longitudinal study.

BMC neurology·2026

Related Experiment Video

Updated: Jan 6, 2026

Implantation of Osmotic Pumps and Induction of Stress to Establish a Symptomatic, Pharmacological Mouse Model for DYT/PARK-ATP1A3 Dystonia
10:41

Implantation of Osmotic Pumps and Induction of Stress to Establish a Symptomatic, Pharmacological Mouse Model for DYT/PARK-ATP1A3 Dystonia

Published on: September 12, 2020

7.9K

Daytime sleepiness and myotonic dystrophy.

Luc Laberge1, Cynthia Gagnon, Yves Dauvilliers

  • 1ÉCOBES-Recherche et transfert, Cégep de Jonquière, 3791, rue de la fabrique, Jonquière, Québec, Canada, G7X 7W2. luc.laberge@cjonquiere.qc.ca

Current Neurology and Neuroscience Reports
|February 23, 2013
PubMed
Summary

Myotonic dystrophy type 1 causes significant sleep problems, especially excessive daytime sleepiness (EDS). This sleepiness likely stems from central nervous system dysfunction, not just breathing issues, impacting patient quality of life.

More Related Videos

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World
10:16

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

9.0K
Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
09:39

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells

Published on: July 29, 2016

15.9K

Related Experiment Videos

Last Updated: Jan 6, 2026

Implantation of Osmotic Pumps and Induction of Stress to Establish a Symptomatic, Pharmacological Mouse Model for DYT/PARK-ATP1A3 Dystonia
10:41

Implantation of Osmotic Pumps and Induction of Stress to Establish a Symptomatic, Pharmacological Mouse Model for DYT/PARK-ATP1A3 Dystonia

Published on: September 12, 2020

7.9K
Human Circadian Phenotyping and Diurnal Performance Testing in the Real World
10:16

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

9.0K
Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
09:39

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells

Published on: July 29, 2016

15.9K

Area of Science:

  • Neurology
  • Sleep Medicine
  • Genetics

Background:

  • Myotonic dystrophy type 1 (DM1) is a chronic neuromuscular disease.
  • Sleep disorders, including excessive daytime sleepiness (EDS), are prominent in DM1 patients.
  • EDS significantly impacts daily functioning and quality of life.

Purpose of the Study:

  • To review the literature on sleep disorders in DM1.
  • To investigate the primary causes of EDS in DM1.
  • To discuss current and needed management strategies for EDS in DM1.

Main Methods:

  • Literature review of studies on DM1 and sleep disorders.
  • Analysis of evidence supporting central vs. peripheral causes of EDS.
  • Discussion of proposed pathogenetic mechanisms and management approaches.

Main Results:

  • DM1 is associated with prominent sleep disorders: EDS, sleep apneas, periodic leg movements, and REM sleep dysregulation.
  • Evidence suggests DM1-related EDS is primarily due to central sleep regulation dysfunction, not sleep-related disordered breathing (SRDB) or fragmentation.
  • Pathogenesis may involve toxic expanded DMPK gene products in the brain/brainstem affecting gene expression and splicing.

Conclusions:

  • SRDB management with noninvasive ventilation is crucial but often insufficient for EDS.
  • EDS in DM1 may persist and require psychostimulants, though consensus is lacking.
  • Further research is needed on EDS discrepancies, cognitive roles, and treatment efficacy.