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Conditioned stimulus control of morphine hyperthermia.

K S Schwarz¹, C L Cunningham

¹Department of Medical Psychology, Oregon Health Sciences University, Portland 97201-3098.

Psychopharmacology

|January 1, 1990

Summary

Learning influences morphine

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Area of Science:

Pharmacology
Neuroscience
Behavioral Science

Background:

Repeated morphine administration can lead to adaptive changes in physiological responses.
Classical conditioning is a form of learning that can modify drug effects.
Previous studies on conditioned morphine hyperthermia have limitations due to confounding factors.

Purpose of the Study:

To investigate the development of conditioned hyperthermia in response to morphine.
To examine the role of classical conditioning in modulating morphine's hyperthermic effects.
To assess if a discrete conditioned stimulus can elicit a conditioned hyperthermic response.

Main Methods:

Rats were surgically implanted with a cannula and biotelemetry device for drug administration and temperature monitoring.
A light/noise stimulus served as the conditioned stimulus (CS).
Intravenous morphine (5 mg/kg) was administered as the unconditioned stimulus (US) to either a paired or unpaired group.

Main Results:

Rats in the paired group developed a conditioned hyperthermic response to the CS alone.
The development of morphine hyperthermia was accelerated by the CS in the paired group.
The conditioned hyperthermic response was observed rapidly and without confounding factors like handling stress.

Conclusions:

Learning significantly affects the body's response to repeated morphine administration.
Classical conditioning can elicit a conditioned hyperthermic response to morphine.
This study provides clear evidence of learning's influence on drug-induced hyperthermia.

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