Related Experiment Videos
[Experiences with the use of ioxithalamate (Telebrix)]
1Radiologische Klinik der Albert-Szent-Györgyi Medizinischen Universität Szeged, Ungarn.
Radiologia Diagnostica
|January 1, 1990
Summary
Ioxitalamate, a low-osmotic contrast medium, was well tolerated in excretion urography and angiography, showing no significant adverse effects in animal studies. Radiographs were of good quality, indicating its suitability for diagnostic imaging.
Area of Science:
- Radiology
- Medical Imaging
- Pharmacology
Context:
- Evaluation of Ioxitalamate (Telebrix-BYK GULDEN) for diagnostic imaging procedures.
- Assessment of tolerance and efficacy in excretion urography and various angiographic applications.
- Inclusion of animal experiments for comprehensive safety and efficacy analysis.
Purpose:
- To determine the safety and efficacy of Ioxitalamate as a contrast medium.
- To evaluate potential adverse effects on physiological parameters and organ function.
- To assess the quality of radiographic images produced by Ioxitalamate.
Summary:
- Ioxitalamate demonstrated good tolerability and produced high-quality radiographs in excretion urography and angiography.
- No significant changes were observed in blood pressure, heart rate, ECG, or key biochemical markers (Se-creatinine, UN-, SGOT, Se-bilirubin).
- Transient proteinuria occurred in a small percentage of cases, with no histological or ultrastructural renal effects noted in canine studies.
Impact:
- Ioxitalamate is a promising contrast medium for investigations requiring low osmotic pressure.
- The findings support the clinical use of Ioxitalamate in urography and angiography.
- This study contributes to the understanding of contrast media safety profiles in medical imaging.