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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

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Related Experiment Video

Updated: May 13, 2026

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

Central nervous system drug evaluation using positron emission tomography.

Mizuho Sekine1, Jun Maeda, Hitoshi Shimada

  • 1Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan. ; Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan.

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology
|February 23, 2013
PubMed
Summary

Positron emission tomography (PET) enables objective measurement of drug effects in the brain. This technique supports rational drug dosing and proof-of-concept studies in mental disorder research.

Keywords:
Dopamine D receptorNorepinephrine transporterOccupancyPositron emission tomographySerotonin transportermicro-PET

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Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
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Published on: October 22, 2019

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Last Updated: May 13, 2026

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Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
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Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

Area of Science:

  • Neuroscience
  • Pharmacology
  • Medical Imaging

Background:

  • Conventional methods for estimating drug effects in mental disorders rely on ethological approaches and in vitro affinity data.
  • Estimating drug dosage and frequency often uses blood kinetics, but this may not reflect drug concentrations in target organs.
  • An objective index for drug effects within the living body remains a challenge in current pharmacological research.

Purpose of the Study:

  • To highlight the utility of Positron Emission Tomography (PET) in assessing drug effects in the brain.
  • To demonstrate the application of PET for rational drug dosing strategies.
  • To showcase PET's role in proof-of-concept studies during drug development for mental disorders.

Main Methods:

  • Utilizing Positron Emission Tomography (PET) to measure the distribution and kinetics of small molecules in the living brain.
  • Focusing on receptor occupancy as a key metric for evaluating drug effects.
  • Applying PET imaging techniques to drug development processes.

Main Results:

  • PET allows for direct, in vivo measurement of drug distribution and kinetics within the brain.
  • Receptor occupancy determined by PET provides an objective index of pharmacological effect.
  • PET facilitates the assessment of drug proof-of-concept in preclinical and clinical settings.

Conclusions:

  • PET imaging offers a significant advancement over traditional methods for evaluating central nervous system drugs.
  • The technique enables rational drug dosing by directly measuring target engagement.
  • PET is a valuable tool for accelerating drug development by providing early proof-of-concept data.