Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Global Regulatory Systems01:28

Global Regulatory Systems

Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LATS kinase activity and tumor suppressor function are regulated by a second autophosphorylation site.

The Journal of biological chemistry·2026
Same author

Patient-derived AMOTL1 mutations lead to defective cell migration and tissue development.

Bioscience reports·2026
Same author

Editorial Expression of Concern: YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity.

Oncogene·2026
Same author

Core Components of the Hippo Pathway.

Cold Spring Harbor perspectives in biology·2026
Same author

Proteasome stress activates YAP/TAZ through the RAP2-MAP4Ks-LATS1/2 pathway and its therapeutic implications in solid tumors.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Nutrient Availability Dictates Cancer Metabolism-Based Therapeutic Responses to Nononcology Drugs.

Cancer research·2025

Related Experiment Video

Updated: May 13, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor

Published on: September 13, 2018

The Hippo pathway: regulators and regulations.

Fa-Xing Yu1, Kun-Liang Guan

  • 1Department of Pharmacology, Moores Cancer Center, University of California at San Diego, La Jolla, California 92093, USA.

Genes & Development
|February 23, 2013
PubMed
Summary
This summary is machine-generated.

The Hippo pathway controls animal cell numbers, impacting development and disease. Actin cytoskeleton integrates signals, regulating proliferation, cell death, and differentiation for tissue homeostasis.

More Related Videos

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

Culturing and Manipulation of O9-1 Neural Crest Cells
08:32

Culturing and Manipulation of O9-1 Neural Crest Cells

Published on: October 9, 2018

Related Experiment Videos

Last Updated: May 13, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor

Published on: September 13, 2018

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

Culturing and Manipulation of O9-1 Neural Crest Cells
08:32

Culturing and Manipulation of O9-1 Neural Crest Cells

Published on: October 9, 2018

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Background:

  • Cell number regulation is vital for animal development and tissue homeostasis.
  • Dysregulation of cell number control can lead to tumor formation or organ degeneration.
  • The Hippo pathway is a key regulator of cell number in Drosophila and mammals.

Purpose of the Study:

  • To review the regulatory mechanisms of the Hippo pathway.
  • To discuss the implications of Hippo pathway dysregulation in physiological and pathological conditions.
  • To highlight the role of the actin cytoskeleton in integrating upstream signals.

Main Methods:

  • Literature review of Hippo pathway research.
  • Analysis of upstream components including cell polarity, mechanotransduction, and GPCR signaling.
  • Focus on the role of the actin cytoskeleton and cellular tension.

Main Results:

  • The Hippo pathway modulates cell proliferation, cell death, and cell differentiation.
  • Upstream regulators like cell polarity, mechanotransduction, and GPCR signaling converge on the Hippo pathway.
  • Actin cytoskeleton and cellular tension act as central mediators integrating these upstream signals.

Conclusions:

  • The Hippo pathway is a critical regulator of cell number and tissue homeostasis.
  • Understanding Hippo pathway mechanisms is essential for addressing diseases like cancer.
  • Actin cytoskeleton dynamics play a pivotal role in Hippo pathway signaling integration.