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A BDNF Val66Met Polymorphism and Ketamine-induced Rapid Antidepressant Action

Kenji Hashimoto1

  • 1Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology
|February 23, 2013
PubMed
Abstract

No abstract available in PubMed .

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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