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A Periprosthetic Joint Candida albicans Infection Model in Mouse
Published on: February 2, 2024
Candida glabrata prosthetic hip infection
Filippo Bartalesi1, Stefania Fallani, Elena Salomoni
1Infectious and Tropical Diseases Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy. bartalesif@aou-careggi.toscana.it
American Journal of Orthopedics (Belle Mead, N.J.)
|February 23, 2013
Summary
This study details a successful treatment for Candida glabrata prosthetic joint infection using a combination antifungal therapy. The approach involved surgery and a six-week course of caspofungin and liposomal amphotericin, leading to successful joint reimplantation.
Area of Science:
- Infectious Diseases
- Mycology
- Orthopedic Surgery
Background:
- Prosthetic joint infections (PJIs) pose significant challenges in orthopedic surgery.
- Candida glabrata is an emerging cause of fungal PJIs, often associated with antifungal resistance.
- Effective treatment strategies for C. glabrata PJI remain limited.
Observation:
- A 60-year-old woman presented with a hip prosthesis infected by Candida glabrata.
- The isolate exhibited dose-dependent susceptibility to fluconazole and voriconazole.
- Initial management involved resection arthroplasty.
Findings:
- A six-week combination therapy with caspofungin and liposomal amphotericin was administered.
- This regimen successfully sterilized the joint.
- Reimplantation arthroplasty was performed successfully following the antifungal treatment.
Implications:
- Combination antifungal therapy can be effective for C. glabrata prosthetic joint infections.
- This case highlights a viable treatment pathway for challenging fungal orthopedic infections.
- Further research into optimal antifungal regimens for PJIs is warranted.
