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Published on: December 6, 2016
Meperidine as the single sedative agent during esophagogastroduodenoscopy, a double-blind, randomized, controlled
Yu-Hsi Hsieh1, Hwai-Jeng Lin, Jin-Jian Hsieh
1Division of Gastroenterology, Department of Medicine, Buddhist Dalin Tzu Chi General Hospital, Chia-Yi, Taiwan. hsieh.yuhsi@msa.hinet.net
Journal of Gastroenterology and Hepatology
|February 26, 2013
Summary
Meperidine significantly reduced patient discomfort and improved tolerance during esophagogastroduodenoscopy (EGD). While some experienced mild dizziness, it did not outweigh the benefits of this sedative approach for EGD procedures.
Area of Science:
- Gastroenterology
- Pharmacology
- Clinical Medicine
Background:
- Esophagogastroduodenoscopy (EGD) in Taiwan often proceeds without sedation, causing patient discomfort.
- Meperidine is used in colonoscopy but less studied for EGD sedation.
Purpose of the Study:
- To investigate meperidine as a single sedative agent for diagnostic EGD.
- To evaluate patient discomfort and tolerance during EGD with meperidine.
Main Methods:
- A prospective randomized study involving 140 patients undergoing EGD.
- Patients received either 25-mg intramuscular meperidine or a placebo.
- Primary outcome was patient-reported discomfort scores; secondary outcomes included endoscopist assessments.
Main Results:
- Meperidine group reported significantly less discomfort during esophageal intubation and the procedure.
- Endoscopists noted better patient tolerance in the meperidine group.
- More patients in the meperidine group experienced transient dizziness post-procedure.
Conclusions:
- Meperidine as a single agent improves patient tolerance and reduces discomfort during diagnostic EGD.
- The benefits of meperidine for EGD sedation appear to outweigh the mild side effect of temporary dizziness.
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