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Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Vascular Spasm01:16

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Antihypertensive Drugs: Action of Calcium Channel Blockers01:18

Antihypertensive Drugs: Action of Calcium Channel Blockers

Calcium ions are essential to contract smooth muscle cells in blood vessels. They enter these cells through voltage-dependent calcium channels, specifically L-type calcium channels in the cell membrane. These L-type calcium channels are integral to the excitation-contraction coupling process in smooth muscle. When a stimulus is received by smooth muscle cells, their membrane depolarizes. This alteration in membrane potential instigates the opening of L-type calcium channels. As a result,...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...

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Related Experiment Video

Updated: May 13, 2026

Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies
12:42

Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies

Published on: July 14, 2018

TRP channels in vascular disorders.

Alexander V Zholos1, Timothy M Curtis

  • 1Centre for Vision & Vascular Science, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast BT12 6BA, Northern Ireland, UK. a.zholos@qub.ac.uk

Current Topics in Medicinal Chemistry
|February 26, 2013
PubMed
Summary

Transient Receptor Potential (TRP) channels are crucial in vascular health, regulating blood vessel tone and function. This review details their roles in vascular diseases like hypertension and injury.

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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

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Last Updated: May 13, 2026

Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies
12:42

Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies

Published on: July 14, 2018

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

Area of Science:

  • Physiology
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Transient Receptor Potential (TRP) channels are increasingly recognized for their significant roles in vascular biology.
  • These channels, permeable to calcium ions (Ca2+), are expressed in vascular smooth muscle and endothelial cells.
  • Their activation is triggered by various stimuli, including receptor activation, Ca2+ store depletion, and mechanical stress.

Purpose of the Study:

  • To review the expanding research on TRP channels in vascular physiology and pathology.
  • To summarize the molecular composition and signaling pathways of vascular TRP channels.
  • To discuss the involvement of TRP channels in diverse vascular disorders.

Main Methods:

  • Literature review of scientific publications on TRP channels and vascular function.
  • Analysis of research on TRP channel expression and function in vascular cells.
  • Synthesis of evidence linking TRP channels to various vascular diseases.

Main Results:

  • Multiple TRP channel subtypes are present in vascular smooth muscle and endothelial cells.
  • These channels facilitate Ca2+ influx in response to physiological and pathological stimuli.
  • Growing evidence implicates TRP channels in hypertension, impaired vasodilation, and vascular injury.

Conclusions:

  • TRP channels are key regulators of vascular tone and function.
  • Dysregulation of TRP channel activity contributes to the pathogenesis of numerous vascular diseases.
  • Targeting TRP channels may offer therapeutic strategies for vascular disorders.