Related Experiment Video

Updated: May 13, 2026

Cell-based Calcium Assay for Medium to High Throughput Screening of TRP Channel Functions using FlexStation 3
07:26

Cell-based Calcium Assay for Medium to High Throughput Screening of TRP Channel Functions using FlexStation 3

Published on: August 17, 2011

Multiple roles of transient receptor potential (TRP) channels in inflammatory conditions and current status of drug

Olivier Radresa1, Michel Paré, Jeffrey S Albert

  • 1O.R.B.I.T. Bioscience Integration and Technologies, Montréal, Canada. oradresa@hotmail.com

Current Topics in Medicinal Chemistry
|February 26, 2013
PubMed

Insights

Transient Receptor Potential (TRP) channels are activated during inflammation, influencing signaling pathways. Research explores their therapeutic potential for inflammatory diseases.

Area of Science:

  • Physiology
  • Pharmacology
  • Immunology

Background:

  • Transient Receptor Potential (TRP) channels are activated by inflammatory mediators and environmental changes.
  • These channels play roles in pro- or anti-inflammatory signaling cascades, involving transcription factors, kinases, and phospholipases.
  • TRP channels are implicated in various inflammatory conditions such as pruritis, cystitis, dermatitis, and asthma.

Purpose of the Study:

  • To summarize key biological findings on TRP channel roles in inflammation.
  • To review drug discovery efforts targeting TRP channels for inflammatory conditions.
  • To provide an overview of the current status and recent developments in the field.

Main Methods:

  • Literature review of biological findings.
  • Analysis of preclinical and clinical drug discovery reports.
  • Synthesis of current research and future directions.

Main Results:

  • TRP channels are integral to inflammatory signaling.
  • Several TRP isoforms are investigated as therapeutic targets.
  • Understanding of TRP channel physiological roles in inflammation is ongoing.

Conclusions:

  • TRP channels are crucial in inflammatory processes.
  • Targeting TRP channels shows therapeutic promise for inflammatory diseases.
  • Further research is needed to fully elucidate TRP channel functions and therapeutic applications.

More Related Videos

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV412:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism.
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...