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Updated: May 13, 2026

Using Live Cell STED Imaging to Visualize Mitochondrial Inner Membrane Ultrastructure in Neuronal Cell Models
Published on: June 30, 2023
Key role of mitochondria in Alzheimer's disease synaptic dysfunction
Virve Cavallucci1, Caterina Ferraina, Marcello D'Amelio
1IRCCS Fondazione Santa Lucia; Via del Fosso di Fiorano 64, 00143 Rome, Italy. v.cavallucci@hsantalucia.it.
Abstract:
Neuronal transmission and functional synapses require mitochondria, which are mainly involved in the generation of energy (ATP and NAD(+)), regulation of cell signaling and calcium homeostasis. Particularly intriguing is emerging data suggesting the relationship between mitochondria and neurotrophic factors that can act at the synaptic level promoting neuronal transmission and plasticity. On the other hand, disturbances in mitochondrial functions might contribute to impaired synaptic transmission and neuronal degeneration in Alzheimer's Disease and other chronic and acute neurodegenerative disorders. Here, we review the molecular mediators controling mitochondrial function and their impact on synaptic dysfunction associated with the pathogenesis of Alzheimer's Disease.
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